Eng
Evaluation of the safety and efficacy of transplantation of cultured autologous multipotent mesenchymal stromal cells from bone marrow in patients with prolonged bone fracture healing and in patients with traumatic bone tissue defects.
Evaluation of the safety and efficacy of injection and surgical methods of transplantation of cultured autologous multipotent mesenchymal stromal cells from human bone marrow in patients with prolonged bone fracture healing and in patients with traumatic defects of bone tissue of the limbs.
The product of cultured multipotent mesenchymal stromal cells from bone marrow, intended for use as a cell transplant for intracutaneous injection and transplantation as a cell suspension or osteopenogenic graft.
The number of transplanted cells is determined individually for each patient, with a count of at least 106 cells per cm3 of interfragmental space.
Two methods of cell transplant insertion have been used in this reserch: